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Calcium

What is Calcium?

Calcium, a crucial mineral in the blood, is fundamental for several vital body functions. It is best known for its role in bone health, where it helps in the formation and maintenance of strong bones and teeth. Calcium is also essential for blood clotting, muscle contraction, and the transmission of nerve signals. In the heart and other muscles, calcium aids in proper functioning, ensuring that muscles contract and relax correctly. Additionally, calcium is involved in releasing hormones and enzymes that affect almost every function in the human body. Dietary calcium interferes with absorption of iron.

Hypocalcemia, or low calcium levels, can lead to a variety of health issues. Symptoms can include muscle cramps or spasms, numbness and tingling in the fingers, fatigue, and, in severe cases, can cause confusion or memory loss. Chronic hypocalcemia can lead to weakened bones, increasing the risk of osteoporosis and fractures. In extreme cases, low calcium levels can result in heart failure or seizures, indicating the critical nature of this mineral in cardiovascular and neurological health. High levels of Magnesium or Phosphate can hinder Calcium absorption. Adequate Vitamin D is crucial for absorption.

Hypercalcemia, or high calcium levels, although less common, can also have serious health consequences. It can result from overactive parathyroid glands, certain cancers, or excessive intake of calcium and vitamin D. Symptoms may include nausea, vomiting, increased thirst and frequent urination, and in severe cases, can lead to kidney stones, bone pain, and irregular heart rhythms. Excessive calcium can hinder magnesium absorption, potentially leading to magnesium deficiency symptoms like muscle cramps and irregular heartbeat.

To maintain healthy blood calcium levels:

  • Ensure an adequate intake of calcium through a balanced diet that includes dairy products, leafy green vegetables, and calcium-fortified foods. The recommended daily intake varies by age and sex.

  • Maintain sufficient vitamin D levels, as it is essential for calcium absorption. Obtain vitamin D through sunlight exposure, diet (fatty fish, egg yolks), and supplements if needed.

  • Engage in regular weight-bearing exercise, which helps maintain strong bones and stimulates calcium absorption.

  • Monitor the intake of other nutrients that can affect calcium absorption, such as iron, magnesium, and phosphate. Consult a healthcare professional if you are concerned about potential interactions.

  • If you have underlying health conditions that affect calcium metabolism, such as parathyroid disorders or kidney disease, work closely with your healthcare provider to manage your calcium levels appropriately.

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Measurement Units

Calcium can be measured in: mEq/L, mg/100mL, mg/dL, mg/L, mg%, mmol/L, µg/mL, µmol/L

Reference Ranges by Age and Gender

Reference ranges represent typical values for healthy individuals. Your healthcare provider must interpret your specific results.

Age Range Gender Unit Optimal Normal Source
All ages All genders mmol/L - 2.2 - 2.7 Goldstein, 1990

Health Impact

Muscle Function​

Essential for muscle contractions and nerve signaling, calcium plays a key role in triggering muscle action. It's also vital for bone health, which provides the structural framework for muscles. Imbalances in calcium levels can lead to muscle cramps, spasms, and overall muscle weakness. In aging population, calcium deficiency may accelerate muscle mass loss.[Kim, 2020][Tu, 2016]

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Academic References

  1. Judd SE, Khazai N, and Tangpricha V. Calcium and vitamin D: skeletal and extraskeletal health (2008). Curr Rheumatol Rep. DOI: 10.1007/s11926-008-0020-y
  2. Betts G. J., DeSaix P., Johnson J. E., Johnson W., Korol O., Kruse DH., Poe B., Wise J. A., Womble M., and Young K. A.. Calcium homeostasis interactions of the skeletal system and other organ systems (2013). Anatomy and Physiology 2e. View Source
  3. Little A. J., Milner J. R., Payne R. B., and Williams R. B.. Interpretation of serum calcium in patients with abnormal serum proteins (1973). British Medical Journal. View Source
  4. Akbari AR, Alam B, Khalil Z, and Sharma H. The Medical Benefits of Vitamin K2 on Calcium-Related Disorders (2021). Nutrients. DOI: 10.3390/nu13020691
  5. de Craen AJ, Breteler MM, Euser SM, Hofman A, Kamper AM, Schram MT, Trompet S, and Westendorp RG. Serum calcium and cognitive function in old age (2007). J Am Geriatr Soc. DOI: 10.1111/j.1532-5415.2007.01418.x
  6. Goldstein DA.. Clinical Methods: The History, Physical, and Laboratory Examinations (1990). Clinical Methods: The History Physical and Laboratory Examinations. View Source
  7. Dai Q, Deng X, and Shu X. Modifying effect of calcium/magnesium intake ratio and mortality: a population-based cohort study (2013). BMJ Open. DOI: 10.1136/bmjopen-2012-002111
  8. Han K, Hong KW, Kim BT, Kim K, Kim YS, Park JY, and Park YC. Longitudinal Observation of Muscle Mass over 10 Years According to Serum Calcium Levels and Calcium Intake among Korean Adults Aged 50 and Older: The Korean Genome and Epidemiology Study (2020). Nutrients. DOI: 10.3390/nu12092856
  9. Peacock M. Calcium metabolism in health and disease (2010). Clin J Am Soc Nephrol. DOI: 10.2215/CJN.05910809
  10. Burckhardt P., Frassetto L., Gannon R., Lambert H., Lanham-New S., Moore J. B., and Torgerson D.. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis (2015). Osteoporosis International . DOI: 10.1007/s00198-014-3006-9
  11. Abou El Niaj H., Bertinato J., Lavergne C., and Plouffe L. J.. Small increases in dietary calcium above normal requirements exacerbate magnesium deficiency in rats fed a low magnesium diet (2014). Magnesium Research. DOI: 10.1684/mrh.2014.0360
  12. Ashley DM, Boyce DS, Jahanmir J, Kenny CM, and Murphy CE. Things We Do for No Reason™: Calculating a "Corrected Calcium" Level (2021). J Hosp Med. DOI: 10.12788/jhm.3619
  13. Basheer M.P., Edakkot Sreekumaran, Kumar K.M., and Ramakrishna T.. A study of serum magnesium calcium and phosphorus level and cognition in the elderly population of South India (2015). Alexandria Journal of Medicine. DOI: 10.1016/j.ajme.2015.11.001
  14. Borodinsky LN, Hamilton AM, Levin JB, and Tu MK. Calcium signaling in skeletal muscle development maintenance and regeneration (2016). Cell Calcium. DOI: 10.1016/j.ceca.2016.02.005
  15. Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health (2015). Integr Med (Encinitas). View Source

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