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Vitamin A

What is Vitamin A?

Vitamin A, a fat-soluble vitamin, is essential for various critical bodily functions. It is crucial for maintaining healthy vision, particularly night vision and overall eye health. Vitamin A also plays a vital role in supporting immune function, skin health, and cell growth. It exists in two primary forms: preformed vitamin A (retinol, found in animal products) and provitamin A (carotenoids, found in plant-based foods), both of which are converted to retinoic acid, the active form of the vitamin in the body. Adequate levels of vitamin A are necessary for these functions, with optimal levels varying based on age, sex, and health status.

Vitamin A deficiency can lead to several health issues, most notably affecting vision. It can cause night blindness (difficulty seeing in low light) and, in more severe cases, lead to xerophthalmia, a condition that can result in blindness. Deficiency also weakens immune function, increases susceptibility to infections, and can lead to skin issues like hyperkeratosis (thickening of the outer layer of the skin). Children and pregnant women are particularly at risk for vitamin A deficiency, which can also contribute to maternal mortality and increased susceptibility to infections like measles and diarrhea in children.

Nutrients that affect Vitamin A include fat, zinc, protein, Vitamin E, Vitamin D, and iron. Fat enhances its absorption, while zinc is crucial for its transport and metabolism. Adequate protein is important for Vitamin A transport, and Vitamin E protects it from oxidative damage. Excessive Vitamin A can interfere with Vitamin D functions and vice versa, though this is rare. Vitamin A also aids in iron metabolism, highlighting the importance of a balanced diet for effective Vitamin A utilization.

Toxicity from excessive vitamin A intake, especially from supplements, can cause hypervitaminosis A, leading to symptoms such as headache, dizziness, nausea, and joint pain. Chronic toxicity can result in more serious effects like liver damage, increased intracranial pressure, and birth defects if high doses are consumed during pregnancy. While toxicity from food sources is rare, it's crucial to maintain a balance, particularly with retinol forms of vitamin A. Ensuring a diet rich in a variety of sources, such as leafy green vegetables, orange and yellow vegetables, fish, and dairy products, typically provides sufficient vitamin A. Supplementation should be undertaken cautiously and under medical guidance to avoid the risk of toxicity.

To maintain healthy Vitamin A levels: - Consume a varied diet rich in both preformed vitamin A and provitamin A sources. Include animal products like liver, fish, and dairy for retinol, and plant-based sources like sweet potatoes, carrots, and leafy greens for carotenoids. - Ensure adequate fat intake with vitamin A-rich meals to enhance absorption, particularly when consuming plant-based sources. - Include zinc-rich foods in your diet, such as oysters, beef, and pumpkin seeds, to support vitamin A metabolism and transport. - Balance your intake of vitamins A, D, and E, as they work synergistically. Consider a well-balanced multivitamin if you're at risk of deficiency.

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Measurement Units

Vitamin A can be measured in: ng/mL, µg/100mL, µg/dL, µg/L, µg%, µmol/L

Reference Ranges by Age and Gender

Reference ranges represent typical values for healthy individuals. Your healthcare provider must interpret your specific results.

Age Range Gender Unit Optimal Normal Source
All ages All genders µg/dL - 30 - 80 Burnham, 2023

Health Impact

Cognitive Function​

Essential for brain health and cognitive function. Vitamin A is involved in learning and memory and has direct effect on hippoccampal neurogenesis. Deficiency can impact cognitive function, although it's more commonly associated with vision and immune system issues. [González, 2022][Bonnet, 2008][Lane, 2005]

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Academic References

  1. Burnham C.-A. D., Chiu R. W. K., Rifai N., Wittwer C., and Young I.. Tietz Textbook of Laboratory Medicine (2023). Tietz Textbook of Laboratory Medicine.
  2. Christian P and West KP Jr. Interactions between zinc and vitamin A: an update (1998). Am J Clin Nutr. DOI: 10.1093/ajcn/68.2.435S
  3. Lithell H, Melhus H, Michaëlsson K, and Vessby B. Serum retinol levels and the risk of fracture (2003). N Engl J Med. DOI: 10.1056/NEJMoa021171
  4. Chew F. and Mejia L. A.. Hematologic effect of supplementing anemic children with vitamin A alone and in combination with iron (1992). The American Journal of Clinical Nutrition. DOI: 10.1093/ajcn/48.3.595
  5. Groff JL, Gropper SS, and Hunt SM. Advanced Nutrition and Human Metabolism (1995). Advanced Nutrition and Human Metabolism.
  6. De la Cruz-Góngora V, González RP, and Rodríguez AS. Serum retinol levels are associated with cognitive function among community-dwelling older Mexican adults (2022). Nutr Neurosci. DOI: 10.1080/1028415X.2021.1913315
  7. Abrous DN, Alfos S, Bonnet E, Higueret P, Pallet V, and Touyarot K. Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats (2008). PLoS One. DOI: 10.1371/journal.pone.0003487
  8. Jackson C, Kolba N, and Tako E. Assessing the Interactions between Zinc and Vitamin A on Intestinal Functionality, Morphology, and the Microbiome In Vivo (Gallus gallus) (2023). Nutrients. DOI: 10.3390/nu15122754
  9. Conaway HH, Henning P, and Lerner UH. Retinoid receptors in bone and their role in bone remodeling (2015). Front Endocrinol (Lausanne). DOI: 10.3389/fendo.2015.00031
  10. Christian P, Fishman S. M., and West KP Jr. The role of vitamins in the prevention and control of anaemia (2000). Public Health Nutrition. DOI: 10.1017/s1368980000000173
  11. Bailey SJ and Lane MA. Role of retinoid signalling in the adult brain (2005). Prog Neurobiol. DOI: 10.1016/j.pneurobio.2005.03.002
  12. Chi YL, Huang CQ, Lin ZK, Ni WF, Tian NF, Wang XY, Wu AM, and Xu HZ. The relationship between vitamin A and risk of fracture: meta-analysis of prospective studies (2014). J Bone Miner Res. DOI: 10.1002/jbmr.2237

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