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Vitamin B7 (Biotin)

What is Vitamin B7 (Biotin)?

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-vitamin crucial in metabolizing fats, carbohydrates, and amino acids. It is essential for the synthesis of fatty acids and in gluconeogenesis. Biotin also maintains the health of the skin, hair, and nails, influencing their strength and appearance. Biotin deficiency, though rare, can result in hair loss, skin rash, depression, lethargy, and neurological symptoms. It can be caused by inadequate dietary intake, prolonged use of anticonvulsant drugs, and genetic disorders affecting biotin metabolism.

Biotin absorption can be impacted by dietary factors and medications. Avidin, found in raw egg whites, binds to biotin and prevents its absorption; cooking neutralizes avidin. Long-term use of certain anticonvulsant medications can lower biotin levels by altering its metabolism or absorption. Chronic alcohol consumption and factors disrupting gut flora, such as prolonged antibiotic use, might affect biotin synthesis and absorption.

Biotin toxicity is virtually non-existent, with excess biotin excreted in urine. Managing biotin levels involves dietary sources like organ meats, eggs, fish, nuts, and seeds, or supplementation for those at risk of deficiency. In cases of disrupted biotin absorption, addressing the underlying causes and dietary adjustments are key for maintaining adequate levels.

To maintain healthy Vitamin B7 (Biotin) levels:

  • Consume a balanced diet that includes biotin-rich foods such as organ meats, eggs (cooked), fish, nuts, seeds, and certain vegetables like sweet potatoes and spinach.

  • If you are at risk of biotin deficiency due to factors such as prolonged antibiotic use, chronic alcohol consumption, or genetic disorders affecting biotin metabolism, consider biotin supplementation under the guidance of a healthcare professional.

  • If you consume raw egg whites regularly, consider reducing your intake or cooking the egg whites thoroughly, as raw egg whites contain avidin, which can interfere with biotin absorption.

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Measurement Units

Vitamin B7 (Biotin) can be measured in: ng/100mL, ng/dL, ng/L, ng%, nmol/L, pg/mL

Reference Ranges by Age and Gender

Reference ranges represent typical values for healthy individuals. Your healthcare provider must interpret your specific results.

Age Range Gender Unit Optimal Normal Source
All ages All genders nmol/L - 0.5 - 2.2 Burnham, 2023

Health Impact

Mood Regulation​

Aids in energy metabolism and is involved in gene regulation. Deficiencies, although rare, can lead to mood changes, lethargy, and neurological symptoms.[Patel, 2020][Mahdavifar, 2021]

Academic References

  1. Burnham C.-A. D., Chiu R. W. K., Rifai N., Wittwer C., and Young I.. Tietz Textbook of Laboratory Medicine (2023). Tietz Textbook of Laboratory Medicine.
  2. Patel V. B.. Molecular Nutrition Vitamins (2020). Molecular Nutrition Vitamins. View Source
  3. Zhang Y. Assessment of biotin interference in thyroid function tests (2020). Medicine (Baltimore). View Source
  4. Dyer D, McCloud E, Moyer MP, Ortiz A, Rubin S, and Said HM. Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid (1998). Am J Physiol. DOI: 10.1152/ajpcell.1998.275.5.C1365
  5. Hosseinzadeh M, Mahdavifar B, Mirzaei M, Salehi-Abargouei A, and Vafa M. Dietary intake of B vitamins and their association with depression anxiety and stress symptoms: A cross-sectional population-based survey (2021). J Affect Disord. DOI: 10.1016/j.jad.2021.03.055
  6. Ylli D. Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin (2021). Thyroid. View Source

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