Vitamin C, also known as ascorbic acid, is a crucial nutrient for human health, renowned for its role as a powerful antioxidant. It's essential for the synthesis of collagen, a protein vital for the maintenance of skin, blood vessels, bones, and cartilage. Vitamin C also enhances the absorption of iron from plant-based foods, bolsters the immune system, and aids in wound healing. As a water-soluble vitamin, it needs to be regularly supplied in the diet since the body cannot store it. Optimal levels of Vitamin C are necessary for these physiological functions and can be maintained through consumption of fruits like oranges, strawberries, kiwi, and vegetables like broccoli, bell peppers, and spinach.
Nutrients that affect Vitamin C include iron, which is better absorbed with Vitamin C, and protein; excessive protein might hinder its absorption. Zinc, in high doses, can interfere with Vitamin C absorption and vice versa. Vitamin C may impact copper metabolism, and it works synergistically with other antioxidants like Vitamin E, helping regenerate oxidized Vitamin E. The interactions with B vitamins and a slight increase in excretion due to caffeine are also important considerations.
Deficiency of Vitamin C leads to scurvy, a condition rarely seen in modern times but can occur with extremely poor dietary habits. Early symptoms of deficiency include weakness, fatigue, and sore gums. As it progresses, scurvy can cause joint pain, poor wound healing, tooth loss, and anemia. Severe Vitamin C deficiency compromises the integrity of blood vessels, leading to bleeding gums and bruising. Children and the elderly, individuals with certain chronic illnesses, smokers, and those with limited dietary variety are at higher risk of deficiency.
Vitamin C toxicity is rare, as excess amounts are excreted in the urine. However, extremely high doses (usually from supplements) can lead to side effects like diarrhea, nausea, and abdominal cramps. There's also a potential risk of excess iron absorption in individuals with conditions like hemochromatosis. For most people, a diet rich in various fruits and vegetables provides adequate Vitamin C, ensuring its antioxidant and immune-boosting benefits without the risk of deficiency or toxicity. Supplementation should be approached cautiously and is generally only necessary for those with identified deficiencies or increased requirements.
To maintain healthy Vitamin C levels:
Consume a variety of vitamin C-rich foods daily, including citrus fruits, berries, kiwi, bell peppers, broccoli, and leafy greens.
Minimize cooking times and temperatures when preparing vitamin C-rich foods, as heat can degrade the vitamin. Opt for steaming or quick stir-frying instead of boiling.
Pair vitamin C-rich foods with iron sources, especially plant-based iron, to enhance absorption.
Avoid smoke (even secondhand smoke), as it depletes vitamin C.
Be mindful of excessive caffeine intake, which can slightly increase vitamin C excretion.
Measurement Units
Vitamin C can be measured in: mg/100mL, mg/dL, mg/L, mg%, µg/mL, µmol/L
Reference Ranges by Age and Gender
Reference ranges represent typical values for healthy individuals. Your healthcare provider must interpret your specific results.
As an antioxidant, vitamin C can reduce oxidative stress and inflammation. It supports various cellular functions of both the innate and adaptive immune system. High vitamin C levels are associated with reduced levels of CRP and other inflammatory markers.[Crook, 2022][Jafarnejad, 2018][Carr, 2017]
Premium
2 More Health Topics Available
Explore 2 additional health topics related to this biomarker in the Health3 app.
Vitamin C significantly enhances iron absorption from plant-based sources, potentially helping optimize ferritin levels in those with deficiency. Studies demonstrate that combining vitamin C with iron-rich meals can increase absorption by up to 300%. This relationship makes vitamin C status crucial for those trying to build iron stores through dietary approaches.[Saunders, 2013]
Vitamin C is one of the factors enhancing absorption of selenium[Groff, 1995].
Premium
1 More Related Biomarker Available
Explore 1 additional biomarker interaction related to this biomarker in the Health3 app.
Academic References
Saunders AV. Iron and vegetarian diets (2013).
Med J Aust.
View Source
Chin K. Y. and Ima-Nirwana S.. Vitamin C and Bone Health: Evidence from Cell Animal and Human Studies (2018).
Curr Drug Targets.
DOI: 10.2174/1389450116666150907100838
Cook J. D. and Monsen E. R.. Vitamin C, the common cold, and iron absorption (1991).
Am J Clin Nutr.
DOI: 10.1093/ajcn/30.2.235
Crook JM, Grundmann O, Horgas AL, Johnson-Mallard V, and Yoon SL. Vitamin C Plasma Levels Associated with Inflammatory Biomarkers CRP and RDW: Results from the NHANES006 Surveys (2003).
Nutrients.
DOI: 10.3390/nu14061254
Carr AC and Maggini S.. Vitamin C and Immune Function (2017).
Nutrients.
DOI: 10.3390/nu9111211
Burnham C.-A. D., Chiu R. W. K., Rifai N., Wittwer C., and Young I.. Tietz Textbook of Laboratory Medicine (2023).
Tietz Textbook of Laboratory Medicine.
Groff JL, Gropper SS, and Hunt SM. Advanced Nutrition and Human Metabolism (1995).
Advanced Nutrition and Human Metabolism.
Brune M., Hallberg L., and Rossander L.. The role of vitamin C in iron absorption (1982).
International Journal for Vitamin and Nutrition Research. Supplement.
View Source
Boccardi V, Hamedifard Z, Hosseini B, Jafarnejad S, and Taghizadeh M. A Meta-analysis of Randomized Control Trials: The Impact of Vitamin C Supplementation on Serum CRP and Serum hs-CRP Concentrations (2018).
Curr Pharm Des.
DOI: 10.2174/1381612824666181017101810
An JH, Choi HK, Chung KH, Kim GS, Koo YT, Lee KU, Song DH, and Yoo HS. Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/β-Catenin/ATF4 Signaling Pathways (2019).
Nutrients.
DOI: 10.3390/nu11030506
Carr AC and Maggini S.. Vitamin C and Immune Function (2017).
Nutrients.
DOI: 10.3390/nu9111211
Brzezińska O, Łukasik Z, Makowska J, and Walczak K. Role of Vitamin C in Osteoporosis Development and Treatment-A Literature Review (2020).
Nutrients.
DOI: 10.3390/nu12082394
Save this biomarker reference for your medical appointments
Share this article:
Was this information helpful?
Thank you! Your feedback helps us improve.
Track Vitamin C in Health3
Monitor your biomarkers, visualize trends, and share insights with your care team.